• There are numerous resources clinicians may

  2019-09-16

  

  There are numerous resources clinicians may use to gather information on the strength of evidence related to pharmacogenetic-based dosing and treatment decisions, as well as specific dosing guidelines, some of which are summarized in this review. These include resources from CPIC, which provides pee

• Here we report for the first time that

  2019-09-12

  Here, we report for the first time that EphB4 contains two NLS sequences and localises to the nucleus.

• br Materials and methods br Results br

  2019-09-11

  Discussion In this study, the N&B analysis showed new evidence regarding the proportion and the oligomerization state of the AT1 and the ETA receptors near or on the plasma membrane.

• The significance of the difference in the DDR binding

  2019-09-10

  The significance of the difference in the DDR2 binding specificity towards fibrillar and non-fibrillar collagens is not understood, but may imply differences in biological responses when chondrocytes bind to different collagens in the growth plate.

• The assessment process is even more difficult when Commercia

  2019-09-09

  The assessment process is even more difficult when Commercial-Off-The-Shelf (COTS) components – whose internals are partially or totally unknown – come into play.

• C PHNO has been described as a full agonist at

  2019-09-07

  [11C]-(+)-PHNO has been described as a full agonist at both D2 and D3 receptors [54,55]. [11C]-(+)-PHNO was initially developed as a PET radiotracer for imaging the high affinity state of the D2 receptor (i.e., highD2) as a means of measuring synaptic dopamine changes in response to pharmacologic challenge [56,57].

• Future analysis could consider using fixed effects also with

  2019-09-06

  Future analysis could consider using fixed effects also with the level set field, , in order to investigate which covariates explain the classification, a feature of the proposed model that we have not yet investigated.

• br Material and methods br

  2019-09-05

  Discussion The results show for the first time that DDRs may be involved in the pathogenic mechanisms of neurodegenerative diseases.

• In S cerevisiae Mek a paralog of the

  2019-09-04

  In S. cerevisiae, Mek1, a paralog of the checkpoint kinase Chk2, mediates cell-cycle arrest in response to meiotic defects (Bailis and Roeder, 2000, Xu et al., 1997).

• Information on the mechanism by which

  2019-09-03

  Information on the mechanism by which parasite infections promote ECM degradation is limited (McKerrow et al., 1983; Andrade, 1994; Lu and Lai, 2013; Thibeaux et al., 2014).

• The large body of structural knowledge that is

  2019-09-02

  The large body of structural knowledge that is currently available for CRM1 has contributed to atomic level and mechanistic understanding of many steps in the CRM1 nuclear export cycle.

• Currently approved anti obesity drugs for long term use such

  2019-08-30

  Currently approved anti-obesity drugs for long term use such as orlistat, lorcaserin and liraglutide are efficient in reduction of weight gain but are limited in usage due to their adverse effect profile and higher cost (Krentz et al., 2016; Mopuri and Islam, 2017).

• HOIP s ability to build linear Ub

  2019-08-29

  HOIP\'s ability to build linear Ub chains arises from a unique domain that follows directly after the RING2 domain, the linear ubiquitin chain-determining domain (LDD) (Fig. 1).

• Based on both the observational and

  2019-08-28

  Based on both the observational and theoretical data generated in this study, it appears that the mechanism(s) underlying lower IFM CPT1 activity is complex.

• The Wnt signaling pathway has been demonstrated

  2019-08-27

  The Wnt signaling pathway has been demonstrated to be responsible for a variety of biological processes.

14428 records 961/962 page Previous Next First page 上5页 961962