• Mechanical Stress, Cytoskeleton, and Autophagy

  2026-08-14

  The reference study provides direct evidence that microfilaments are central to autophagy induced by cellular compression, while microtubules make a supporting contribution. Its combination of cytoskeletal perturbation, fluorescence-based analysis, and western blotting clarifies how mechanical inputs may be converted into degradative responses.

• HyperPFU™ High-Fidelity DNA Polymerase Guide

  2026-08-13

  HyperPFU™ high-fidelity DNA polymerase is intended for accurate amplification of long, GC-rich, inhibitor-affected, or otherwise difficult DNA templates. It produces blunt-ended products for cloning and sequencing workflows, but it is not the appropriate choice when 3′-A overhangs or sticky ends are required.

• Molecular Basis of TRPM3 Regulation by Neurosteroids

  2026-08-13

  The reference study combines cryo-electron microscopy, electrophysiology, molecular dynamics, and biochemical analysis to define how pregnenolone sulfate, CIM 0216, and primidone regulate TRPM3. Its structures connect ligand recognition with channel gating and disease-associated gain-of-function mutations, providing a mechanistic framework for studying TRPM3 in pain and neurodevelopmental disease.

• Tetrandrine Workflows for Ion Channel Research

  2026-08-12

  Tetrandrine enables a practical bridge from calcium-channel assays to inflammation, neuroscience, and exploratory structure-based screening. This workflow emphasizes DMSO handling, orthogonal validation, assay controls, and clear limits when translating a natural-product signal into mechanism.

• Sex Differences in Cannabinoid Withdrawal Behaviors

  2026-08-12

  Brewer and colleagues show that withdrawal from chronic WIN 55,212-2 exposure produces qualitatively different somatic and anxiety-like behavioral profiles in male and female rats. The study highlights why sex, withdrawal timing, antagonist dose, and locomotor controls must be integrated when modeling synthetic cannabinoid dependence.

• CBD and the Multidimensional Biology of Orofacial Pain

  2026-08-11

  This 2026 study shows that cannabidiol reduces inflammatory pain while also improving anxiety-like, depression-like, and cognitive abnormalities in mouse models. Its main contribution is a mechanistic separation of peripheral CB2-linked anti-inflammatory effects from central CB1-associated modulation of pain processing and serotonin dynamics.

• TAK-242 Workflows for TLR4 Inflammation Studies

  2026-08-11

  Build cleaner LPS challenge assays, neuroinflammation studies, and immune-oncology controls with TAK-242 (Resatorvid). This workflow-focused guide shows how to separate ligand-specific biology from technical failure while using selective TLR4 signaling pathway modulation.

• Phosphatase Inhibitor Cocktail 1 for CD59 Signaling

  2026-08-10

  Learn how Phosphatase Inhibitor Cocktail 1 supports phosphorylation-state preservation when studying the CD59–JAK2–STAT3 axis in pancreatic cancer. This assay-focused guide explains component coverage, workflow decisions, controls, and limitations beyond generic phosphoproteomics guidance.

• Capsaicin Workflows for TRPV1 and KDM1A Research

  2026-08-09

  Capsaicin, also called (E)-Capsaicin, connects rapid TRPV1 ion channel activation with reversible KDM1A/LSD1 inhibition. This guide turns that dual biology into practical workflows for sensory-neuron, inflammation, and gastric-cancer studies, with formulation controls and troubleshooting steps for reproducible results.

• 2'3'-cGAMP Beyond STING: A Translational Playbook

  2026-08-08

  2'3'-cGAMP is widely used as a direct STING activator, but emerging evidence suggests that its biology extends beyond canonical type I interferon signaling. This thought-leadership guide shows how translational researchers can use 2'3'-cGAMP (sodium salt) to separate STING-dependent effects from broader cGAMP biology, design more discriminating experiments, and build stronger hypotheses for immunotherapy research, cancer biology, inflammation, and antiviral studies.

• Proteoform-Specific Drug Targeting in Native Membranes

  2026-08-07

  Lutomski and colleagues developed a native mass-spectrometry workflow that releases membrane proteins and signaling complexes directly from retinal disc membranes, preserving proteoform-specific interaction information. The study shows how lipid modifications and proteoform identity influence G-protein assembly and the off-target binding of PDE5 inhibitors to retinal PDE6, providing a framework for more precise drug-discovery studies.

• Nonivamide: TRPV1 Agonism for Translational Oncology and Neu

  2026-08-07

  Nonivamide, a capsaicin analog and selective TRPV1 agonist, is reshaping strategies in cancer and neuroimmune translational research. This article elucidates its mechanistic pathways—including mitochondrial apoptosis and reactive oxygen species modulation—and translates these findings into actionable guidance for in vitro, in vivo, and disease model applications. By integrating new evidence on TRPV1's role in sensory neuron cross-talk and allokinesis, we map a path for next-generation protocol optimization and cross-domain insight beyond conventional product literature.

• Cleavage-Resistant TREM2 Enhances Macrophage Efferocytosis i

  2026-08-06

  Dong et al. engineered a synthetic, cleavage-resistant TREM2 receptor (CRT) that amplifies macrophage efferocytosis and mitigates inflammation by resisting ADAM17-mediated shedding. Their innovative use of phosphatidylserine-functionalized lipid nanoparticles for selective mRNA delivery offers a promising therapeutic strategy for diseases associated with defective apoptotic cell clearance.

• Tetrandrine Alkaloid: Applied Protocols for Ion Channel Rese

  2026-08-06

  Tetrandrine alkaloid stands out for its robust DMSO solubility and reproducibility in ion channel modulation and inflammation studies. This article details practical workflows, troubleshooting strategies, and advanced applications that empower researchers in neuroscience, cancer biology, and beyond.

• AMG 9810: Advanced TRPV1 Antagonist Workflows in Pain Resear

  2026-08-05

  Unlock the full potential of AMG 9810 as a nanomolar-potency TRPV1 antagonist for dissecting pain and metabolic stress signaling. This guide delivers practical workflows, troubleshooting strategies, and unique translational insights—bridging cellular signaling with real-world assay optimization.

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